diff --git a/.github/workflows/github-actions.yml b/.github/workflows/github-actions.yml
index 25ea5ae..1b00b84 100644
--- a/.github/workflows/github-actions.yml
+++ b/.github/workflows/github-actions.yml
@@ -22,6 +22,13 @@ jobs:
       - run: sudo apt install libbluetooth-dev
       - run: mkdir build && pushd build && cmake -DGATTLIB_FORCE_DBUS=TRUE -DCMAKE_BUILD_TYPE=Release .. && make
 
+  build-release-without-python-support:
+    runs-on: ubuntu-latest
+    steps:
+      - uses: actions/checkout@v4
+      - run: sudo apt install libbluetooth-dev
+      - run: mkdir build && pushd build && cmake -DCMAKE_BUILD_TYPE=Release -DGATTLIB_PYTHON_INTERFACE=OFF .. && make
+
   generate-python-binary-packages:
     runs-on: ubuntu-latest
     steps:
diff --git a/common/gattlib_callback_connected_device.c b/common/gattlib_callback_connected_device.c
index 282c9fe..a4982cc 100644
--- a/common/gattlib_callback_connected_device.c
+++ b/common/gattlib_callback_connected_device.c
@@ -6,6 +6,7 @@
 
 #include "gattlib_internal.h"
 
+#if defined(WITH_PYTHON)
 void gattlib_connected_device_python_callback(void *adapter, const char *dst, gatt_connection_t* connection, int error, void* user_data) {
 	struct gattlib_python_args* args = user_data;
 	PyObject *result;
@@ -43,6 +44,7 @@ void gattlib_connected_device_python_callback(void *adapter, const char *dst, ga
 ON_ERROR:
 	PyGILState_Release(d_gstate);
 }
+#endif
 
 static gpointer _gattlib_connected_device_thread(gpointer data) {
 	gatt_connection_t* connection = data;
@@ -63,7 +65,11 @@ static void* _connected_device_thread_args_allocator(va_list args) {
 void gattlib_on_connected_device(gatt_connection_t* connection) {
 	gattlib_handler_dispatch_to_thread(
 		&connection->on_connection,
+#if defined(WITH_PYTHON)
 		gattlib_connected_device_python_callback /* python_callback */,
+#else
+		NULL, // No Python support. So we do not need to check the callback against Python callback
+#endif
 		_gattlib_connected_device_thread /* thread_func */,
 		"gattlib_connected_device" /* thread_name */,
 		_connected_device_thread_args_allocator /* thread_args_allocator */,
diff --git a/common/gattlib_callback_disconnected_device.c b/common/gattlib_callback_disconnected_device.c
index 7fb6b21..84acbce 100644
--- a/common/gattlib_callback_disconnected_device.c
+++ b/common/gattlib_callback_disconnected_device.c
@@ -6,6 +6,7 @@
 
 #include "gattlib_internal.h"
 
+#if defined(WITH_PYTHON)
 void gattlib_disconnected_device_python_callback(gatt_connection_t* connection, void *user_data) {
 	struct gattlib_python_args* args = user_data;
 	PyObject *result;
@@ -27,6 +28,7 @@ void gattlib_disconnected_device_python_callback(gatt_connection_t* connection,
 
 	PyGILState_Release(d_gstate);
 }
+#endif
 
 void gattlib_on_disconnected_device(gatt_connection_t* connection) {
 	if (connection->on_disconnection.callback.callback == NULL) {
@@ -35,11 +37,13 @@ void gattlib_on_disconnected_device(gatt_connection_t* connection) {
 		return;
 	}
 
+#if defined(WITH_PYTHON)
 	// Check if we are using the Python callback, in case of Python argument we keep track of the argument to free them
 	// once we are done with the handler.
 	if ((gattlib_disconnection_handler_t)connection->on_disconnection.callback.callback == gattlib_disconnected_device_python_callback) {
 		connection->on_disconnection.python_args = connection->on_disconnection.user_data;
 	}
+#endif
 
 	// For GATT disconnection we do not use thread to ensure the callback is synchronous.
 	connection->on_disconnection.callback.disconnection_handler(connection, connection->on_disconnection.user_data);
diff --git a/common/gattlib_callback_discovered_device.c b/common/gattlib_callback_discovered_device.c
index 4a13020..9306843 100644
--- a/common/gattlib_callback_discovered_device.c
+++ b/common/gattlib_callback_discovered_device.c
@@ -6,6 +6,7 @@
 
 #include "gattlib_internal.h"
 
+#if defined(WITH_PYTHON)
 void gattlib_discovered_device_python_callback(void *adapter, const char* addr, const char* name, void *user_data) {
 	struct gattlib_python_args* args = user_data;
 	PyObject *result;
@@ -42,6 +43,7 @@ void gattlib_discovered_device_python_callback(void *adapter, const char* addr,
 ON_ERROR:
 	PyGILState_Release(d_gstate);
 }
+#endif
 
 struct gattlib_discovered_device_thread_args {
 	struct gattlib_adapter* gattlib_adapter;
@@ -87,7 +89,11 @@ static void* _discovered_device_thread_args_allocator(va_list args) {
 void gattlib_on_discovered_device(struct gattlib_adapter* gattlib_adapter, OrgBluezDevice1* device1) {
 	gattlib_handler_dispatch_to_thread(
 		&gattlib_adapter->ble_scan.discovered_device_callback,
+#if defined(WITH_PYTHON)
 		gattlib_discovered_device_python_callback /* python_callback */,
+#else
+		NULL, // No Python support. So we do not need to check the callback against Python callback
+#endif
 		_gattlib_discovered_device_thread /* thread_func */,
 		"gattlib_discovered_device" /* thread_name */,
 		_discovered_device_thread_args_allocator /* thread_args_allocator */,
diff --git a/common/gattlib_callback_notification_device.c b/common/gattlib_callback_notification_device.c
index 86e19fc..abe622d 100644
--- a/common/gattlib_callback_notification_device.c
+++ b/common/gattlib_callback_notification_device.c
@@ -6,6 +6,7 @@
 
 #include "gattlib_internal.h"
 
+#if defined(WITH_PYTHON)
 void gattlib_notification_device_python_callback(const uuid_t* uuid, const uint8_t* data, size_t data_length, void* user_data) {
 	struct gattlib_python_args* args = user_data;
 	char uuid_str[MAX_LEN_UUID_STR + 1];
@@ -42,6 +43,7 @@ void gattlib_notification_device_python_callback(const uuid_t* uuid, const uint8
 
 	PyGILState_Release(d_gstate);
 }
+#endif
 
 struct gattlib_notification_device_thread_args {
 	gatt_connection_t* connection;
diff --git a/common/gattlib_common.c b/common/gattlib_common.c
index 4f626bf..f1f6e86 100644
--- a/common/gattlib_common.c
+++ b/common/gattlib_common.c
@@ -147,6 +147,7 @@ void gattlib_handler_free(struct gattlib_handler* handler) {
 	// Reset callback to stop calling it after we stopped
 	handler->callback.callback = NULL;
 
+#if defined(WITH_PYTHON)
 	if (handler->python_args != NULL) {
 		struct gattlib_python_args* args = handler->python_args;
 		Py_DECREF(args->callback);
@@ -155,6 +156,7 @@ void gattlib_handler_free(struct gattlib_handler* handler) {
 		free(handler->python_args);
 		handler->python_args = NULL;
 	}
+#endif
 
 	if (handler->thread_pool != NULL) {
 		g_thread_pool_free(handler->thread_pool, FALSE /* immediate */, TRUE /* wait */);
@@ -175,11 +177,13 @@ void gattlib_handler_dispatch_to_thread(struct gattlib_handler* handler, void (*
 		return;
 	}
 
+#if defined(WITH_PYTHON)
 	// Check if we are using the Python callback, in case of Python argument we keep track of the argument to free them
 	// once we are done with the handler.
 	if (handler->callback.callback == python_callback) {
 		handler->python_args = handler->user_data;
 	}
+#endif
 
 	// We create a thread to ensure the callback is not blocking the mainloop
 	va_list args;
diff --git a/common/gattlib_internal_defs.h b/common/gattlib_internal_defs.h
index e11eb52..148542b 100644
--- a/common/gattlib_internal_defs.h
+++ b/common/gattlib_internal_defs.h
@@ -16,10 +16,12 @@
 
 #include "gattlib.h"
 
+#if defined(WITH_PYTHON)
 struct gattlib_python_args {
 	PyObject* callback;
 	PyObject* args;
 };
+#endif
 
 struct gattlib_handler {
 	union {
@@ -35,8 +37,10 @@ struct gattlib_handler {
 	GThread *thread;
 	// Thread pool
 	GThreadPool *thread_pool;
+#if defined(WITH_PYTHON)
 	// In case of Python callback and argument, we keep track to free it when we stopped to discover BLE devices
 	void* python_args;
+#endif
 };
 
 struct _gatt_connection_t {
diff --git a/dbus/CMakeLists.txt b/dbus/CMakeLists.txt
index 1df82af..0aa2106 100644
--- a/dbus/CMakeLists.txt
+++ b/dbus/CMakeLists.txt
@@ -78,7 +78,6 @@ set(gattlib_SRCS gattlib.c
                  ${CMAKE_CURRENT_LIST_DIR}/../common/gattlib_callback_disconnected_device.c
                  ${CMAKE_CURRENT_LIST_DIR}/../common/gattlib_callback_discovered_device.c
                  ${CMAKE_CURRENT_LIST_DIR}/../common/gattlib_callback_notification_device.c
-                 ${CMAKE_CURRENT_LIST_DIR}/../common/gattlib_callback_python.c
                  ${CMAKE_CURRENT_LIST_DIR}/../common/logging_backend/${GATTLIB_LOG_BACKEND}/gattlib_logging.c
                  ${CMAKE_CURRENT_LIST_DIR}/../common/mainloop/gattlib_glib_mainloop.c
                  ${CMAKE_CURRENT_BINARY_DIR}/org-bluez-adaptater1.c
@@ -87,6 +86,10 @@ set(gattlib_SRCS gattlib.c
                  ${CMAKE_CURRENT_BINARY_DIR}/org-bluez-gattdescriptor1.c
                  ${CMAKE_CURRENT_BINARY_DIR}/org-bluez-gattservice1.c)
 
+if (GATTLIB_PYTHON_INTERFACE)
+  list(APPEND gattlib_SRCS ${CMAKE_CURRENT_LIST_DIR}/../common/gattlib_callback_python.c)
+endif()
+
 if (BLUEZ_VERSION_MINOR GREATER 40)
 	list(APPEND gattlib_SRCS ${CMAKE_CURRENT_BINARY_DIR}/org-bluez-battery1.c)
 endif()