diff --git a/gnu/packages/ruby.scm b/gnu/packages/ruby.scm
index da77524bb5..51098919ca 100644
--- a/gnu/packages/ruby.scm
+++ b/gnu/packages/ruby.scm
@@ -4086,14 +4086,14 @@ generation.")
 (define-public ruby-sequel
   (package
     (name "ruby-sequel")
-    (version "4.40.0")
+    (version "4.49.0")
     (source
      (origin
        (method url-fetch)
        (uri (rubygems-uri "sequel" version))
        (sha256
         (base32
-         "0r39dv3yprai0cy7hslfxswjr4fg783xwxskmbih8ry24f18lbk0"))))
+         "010p4a60npppvgbyw7pq5xia8aydpgxdlhh3qjm2615kwjsw3fl8"))))
     (build-system ruby-build-system)
     (arguments
      '(#:tests? #f)) ; Avoid dependency loop with ruby-minitest-hooks.