diff --git a/gnu/packages/python.scm b/gnu/packages/python.scm
index d091157d8a..dbb5ccb52e 100644
--- a/gnu/packages/python.scm
+++ b/gnu/packages/python.scm
@@ -363,8 +363,74 @@ data types.")
                               ;; versions of Python.
                               "Lib/test/test_socket.py"))
                   #t))))
-    (arguments (substitute-keyword-arguments (package-arguments python-2)
-                 ((#:tests? _) #t)))
+    (arguments
+     (substitute-keyword-arguments (package-arguments python-2)
+       ((#:tests? _) #t)
+       ((#:phases phases)
+        `(modify-phases ,phases
+           (add-after 'unpack 'patch-timestamp-for-pyc-files
+             (lambda _
+               ;; We set DETERMINISTIC_BUILD to only override the mtime when
+               ;; building with Guix, lest we break auto-compilation in
+               ;; environments.
+               (setenv "DETERMINISTIC_BUILD" "1")
+               (substitute* "Lib/py_compile.py"
+                 (("source_stats\\['mtime'\\]")
+                  "(1 if 'DETERMINISTIC_BUILD' in os.environ else source_stats['mtime'])"))
+
+               ;; Use deterministic hashes for strings, bytes, and datetime
+               ;; objects.
+               (setenv "PYTHONHASHSEED" "0")
+
+               ;; Reset mtime when validating bytecode header.
+               (substitute* "Lib/importlib/_bootstrap_external.py"
+                 (("source_mtime = int\\(source_stats\\['mtime'\\]\\)")
+                  "source_mtime = 1"))
+               #t))
+           ;; These tests fail because of our change to the bytecode
+           ;; validation.  They fail because expected exceptions do not get
+           ;; thrown.  This seems to be no problem.
+           (add-after 'unpack 'disable-broken-bytecode-tests
+             (lambda _
+               (substitute* "Lib/test/test_importlib/source/test_file_loader.py"
+                 (("test_bad_marshal")
+                  "disable_test_bad_marshal")
+                 (("test_no_marshal")
+                  "disable_test_no_marshal")
+                 (("test_non_code_marshal")
+                  "disable_test_non_code_marshal"))
+               #t))
+           ;; Unset DETERMINISTIC_BUILD to allow for tests that check that
+           ;; stale pyc files are rebuilt.
+           (add-before 'check 'allow-non-deterministic-compilation
+             (lambda _ (unsetenv "DETERMINISTIC_BUILD") #t))
+           ;; We need to rebuild all pyc files for three different
+           ;; optimization levels to replace all files that were not built
+           ;; deterministically.
+
+           ;; FIXME: Without this phase we have close to 2000 files that
+           ;; differ across different builds of this package.  With this phase
+           ;; there are about 500 files left that differ.
+           (add-after 'install 'rebuild-bytecode
+             (lambda* (#:key outputs #:allow-other-keys)
+               (setenv "DETERMINISTIC_BUILD" "1")
+               (let ((out (assoc-ref outputs "out")))
+                 (for-each
+                  (lambda (opt)
+                    (format #t "Compiling with optimization level: ~a\n"
+                            (if (null? opt) "none" (car opt)))
+                    (for-each (lambda (file)
+                                (apply invoke
+                                       `(,(string-append out "/bin/python3")
+                                         ,@opt
+                                         "-m" "compileall"
+                                         "-f" ; force rebuild
+                                         ;; Don't build lib2to3, because it's Python 2 code.
+                                         ;; Also don't build obviously broken test code.
+                                         "-x" "(lib2to3|test/bad.*)"
+                                         ,file)))
+                              (find-files out "\\.py$")))
+                  (list '() '("-O") '("-OO"))))))))))
     (native-search-paths
      (list (search-path-specification
             (variable "PYTHONPATH")