diff --git a/gnu/packages/game-development.scm b/gnu/packages/game-development.scm
index 34a015bdf7..8a29297805 100644
--- a/gnu/packages/game-development.scm
+++ b/gnu/packages/game-development.scm
@@ -652,6 +652,8 @@ etc.")
               (uri (string-append "https://github.com/liballeg/allegro5/releases"
                                   "/download/" version "/allegro-"
                                   version ".tar.gz"))
+              (patches (search-patches
+                        "allegro-fix-compilation-mesa-18.2.5-and-later.patch"))
               (sha256
                (base32
                 "1w9a5yqi5q03b2qvmx5ff90paz0xbr9cy7i7f0xiqa65ava66q9l"))))
diff --git a/gnu/packages/patches/allegro-fix-compilation-mesa-18.2.5-and-later.patch b/gnu/packages/patches/allegro-fix-compilation-mesa-18.2.5-and-later.patch
new file mode 100644
index 0000000000..fa273a5dfa
--- /dev/null
+++ b/gnu/packages/patches/allegro-fix-compilation-mesa-18.2.5-and-later.patch
@@ -0,0 +1,41 @@
+Fixes compilation with Mesa >= 18.2.5.
+
+Taken from upstream:
+
+https://github.com/liballeg/allegro5/commit/a40d30e21802ecf5c9382cf34af9b01bd3781e47
+
+diff --git a/include/allegro5/allegro_opengl.h b/include/allegro5/allegro_opengl.h
+index 0f86a6768..652dd024e 100644
+--- a/include/allegro5/allegro_opengl.h
++++ b/include/allegro5/allegro_opengl.h
+@@ -103,10 +103,14 @@
+
+ /* HACK: Prevent both Mesa and SGI's broken headers from screwing us */
+ #define __glext_h_
++#define __gl_glext_h_
+ #define __glxext_h_
++#define __glx_glxext_h_
+ #include <GL/gl.h>
+ #undef  __glext_h_
++#undef  __gl_glext_h_
+ #undef  __glxext_h_
++#undef  __glx_glxext_h_
+
+ #endif /* ALLEGRO_MACOSX */
+
+diff --git a/include/allegro5/opengl/GLext/glx_ext_defs.h b/include/allegro5/opengl/GLext/glx_ext_defs.h
+index 49c502091..fba8aea5d 100644
+--- a/include/allegro5/opengl/GLext/glx_ext_defs.h
++++ b/include/allegro5/opengl/GLext/glx_ext_defs.h
+@@ -1,7 +1,9 @@
+ /* HACK: Prevent both Mesa and SGI's broken headers from screwing us */
+ #define __glxext_h_
++#define __glx_glxext_h_
+ #include <GL/glx.h>
+ #undef __glxext_h_
++#undef __glx_glxext_h_
+
+ #ifndef GLX_VERSION_1_3
+ #define _ALLEGRO_GLX_VERSION_1_3
+--
+2.20.0