diff --git a/doc/guix.texi b/doc/guix.texi
index 4fbe057614..0a3827911b 100644
--- a/doc/guix.texi
+++ b/doc/guix.texi
@@ -6217,6 +6217,9 @@ Whether to authorize the substitute key for @code{hydra.gnu.org}
 @item @code{use-substitutes?} (default: @code{#t})
 Whether to use substitutes.
 
+@item @code{substitute-urls} (default: @var{%default-substitute-urls})
+The list of URLs where to look for substitutes by default.
+
 @item @code{extra-options} (default: @code{'()})
 List of extra command-line options for @command{guix-daemon}.
 
diff --git a/gnu/services/base.scm b/gnu/services/base.scm
index 336cc4dec9..618cef8a98 100644
--- a/gnu/services/base.scm
+++ b/gnu/services/base.scm
@@ -751,6 +751,8 @@ failed to register hydra.gnu.org public key: ~a~%" status))))))))
                     (default #t))
   (use-substitutes? guix-configuration-use-substitutes? ;Boolean
                     (default #t))
+  (substitute-urls  guix-configuration-substitute-urls ;list of strings
+                    (default %default-substitute-urls))
   (extra-options    guix-configuration-extra-options ;list of strings
                     (default '()))
   (lsof             guix-configuration-lsof       ;<package>
@@ -765,7 +767,8 @@ failed to register hydra.gnu.org public key: ~a~%" status))))))))
   "Return a <dmd-service> for the Guix daemon service with CONFIG."
   (match config
     (($ <guix-configuration> guix build-group build-accounts authorize-key?
-                             use-substitutes? extra-options lsof lsh)
+                             use-substitutes? substitute-urls extra-options
+                             lsof lsh)
      (list (dmd-service
             (documentation "Run the Guix daemon.")
             (provision '(guix-daemon))
@@ -777,6 +780,7 @@ failed to register hydra.gnu.org public key: ~a~%" status))))))))
                       #$@(if use-substitutes?
                              '()
                              '("--no-substitutes"))
+                      "--substitute-urls" #$(string-join substitute-urls)
                       #$@extra-options)
 
                 ;; Add 'lsof' (for the GC) and 'lsh' (for offloading) to the