diff --git a/gnu/packages/bioinformatics.scm b/gnu/packages/bioinformatics.scm
index 73cca16717..bb0e8c73c7 100644
--- a/gnu/packages/bioinformatics.scm
+++ b/gnu/packages/bioinformatics.scm
@@ -12837,7 +12837,7 @@ once.  This package provides tools to perform Drop-seq analyses.")
              #t)))))
     (inputs
      `(("gzip" ,gzip)
-       ("snakemake" ,snakemake)
+       ("snakemake" ,snakemake-4)
        ("fastqc" ,fastqc)
        ("multiqc" ,multiqc)
        ("star" ,star)
@@ -12931,7 +12931,7 @@ expression report comparing samples in an easily configurable manner.")
        ("fastqc" ,fastqc)
        ("bowtie" ,bowtie)
        ("idr" ,idr)
-       ("snakemake" ,snakemake)
+       ("snakemake" ,snakemake-4)
        ("samtools" ,samtools)
        ("bedtools" ,bedtools)
        ("kentutils" ,kentutils)))
@@ -12992,7 +12992,7 @@ in an easily configurable manner.")
        ("ghc-pandoc-citeproc" ,ghc-pandoc-citeproc-with-pandoc-1)
        ("python-wrapper" ,python-wrapper)
        ("python-pyyaml" ,python-pyyaml)
-       ("snakemake" ,snakemake)
+       ("snakemake" ,snakemake-4)
        ("bismark" ,bismark)
        ("fastqc" ,fastqc)
        ("bowtie" ,bowtie)
@@ -13041,7 +13041,7 @@ methylation and segmentation.")
        ("python-loompy" ,python-loompy)
        ("ghc-pandoc" ,ghc-pandoc-1)
        ("ghc-pandoc-citeproc" ,ghc-pandoc-citeproc-with-pandoc-1)
-       ("snakemake" ,snakemake)
+       ("snakemake" ,snakemake-4)
        ("star" ,star)
        ("r-minimal" ,r-minimal)
        ("r-argparser" ,r-argparser)
diff --git a/gnu/packages/python.scm b/gnu/packages/python.scm
index a6e3ebb9d6..e9fb9f529f 100644
--- a/gnu/packages/python.scm
+++ b/gnu/packages/python.scm
@@ -5206,6 +5206,24 @@ providing a clean and modern domain specific specification language (DSL) in
 Python style, together with a fast and comfortable execution environment.")
     (license license:expat)))
 
+;; This is currently needed for the pigx-* packages.
+(define-public snakemake-4
+  (package (inherit snakemake)
+    (version "4.4.0")
+    (source
+     (origin
+       (method url-fetch)
+       (uri (pypi-uri "snakemake" version))
+       (sha256
+        (base32 "0g0paia4z7w3srnqdmavq3hrb2x7qnpf81jx50njl0p7y4y0j8jv"))))
+    (propagated-inputs
+     `(("python-wrapt" ,python-wrapt)
+       ("python-requests" ,python-requests)
+       ("python-appdirs" ,python-appdirs)
+       ("python-configargparse" ,python-configargparse)
+       ("python-pyyaml" ,python-pyyaml)
+       ("python-ratelimiter" ,python-ratelimiter)))))
+
 (define-public python-pyqrcode
   (package
     (name "python-pyqrcode")